眼科

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结核性葡萄膜炎诊治困境及对策

彭晓燕 毛羽   

  1. 100005 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室
  • 收稿日期:2019-09-03 出版日期:2019-09-25 发布日期:2019-09-24
  • 通讯作者: 彭晓燕, Email:drpengxy@163.com
  • 基金资助:
    首都医科大学附属北京同仁医院重点医学专业发展计划(trzdyxzy201801)

The dilemma and countermeasure of diagnosis and treatment in tuberculous uveitis

PENG Xiao-yan, MAO Yu   

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing 100005, China
  • Received:2019-09-03 Online:2019-09-25 Published:2019-09-24
  • Contact: PENG Xiao-yan, Email:drpengxy@163.com

摘要: 结核性葡萄膜炎是由结核杆菌直接侵犯或由之诱导的免疫反应所致的一组表现各异、主要累及葡萄膜的炎症性疾病,其诊断和治疗一直存在诸多困难。由于大多数拟诊的患者并不存在结核的系统性活动性病变,建立这种无症状的系统感染与葡萄膜炎之间的关系面临过度诊断的风险。而采用眼内液或组织进行病原学或病理学检查受到诊断效率低和创伤明显的限制。治疗结核性葡萄膜炎同样因缺乏病原菌的药物培养结果指导和抗结核药物存在各种毒副作用而进退两难。在现有的条件下应正确解读各项结核相关辅助检查结果,提高系统结核的正确诊断率,减少“特发性葡萄膜炎”中漏诊结核原因的机会;不断总结结核性葡萄膜炎的临床特征,提高验前概率,减少误诊的可能;要强调进行标准化的拟诊结核性葡萄膜炎的治疗,从临床预后中反证诊断并改善治疗预后。(眼科, 2019, 28: 325-327)

关键词: 结核性葡萄膜炎/诊断, 结核性葡萄膜炎/治疗

Abstract: Tuberculous uveitis is a group of inflammatory diseases with different clinical manifestations, which mainly involving the uvea and caused by the direct invasion or immune reaction of tuberculous bacilli. There are many difficulties in diagnosis and treatment of tuberculous uveitis. Since most of the patients with presumed diagnosis of tuberculous uveitis lack of active systemic tuberculosis, to establish an association between this asymptomatic systemic infection and the uveitis carries a great risk of over-diagnosis. The use of etiological or pathological examination of intraocular fluid or tissue is limited by low detection rate and risk of invasive operations. The dilemma of treatment for tuberculous uveitis lies in the lack of culture results of pathogenic bacteria and various adverse toxic effects of anti-tuberculosis drugs. Currently, the main countermeasures to get out of the predicament include understanding of tuberculosis-related examinations, improving diagnostic accuracy of systemic tuberculous, reducing the rate of missed and misdiagnosis of tuberculosis uveitis, and summing up of clinical features of tuberculous uveitis. In addition, the standardized treatment of presumed tuberculous uveitis to retrospectively confirm the diagnosis and improve treatment the prognosis. (Ophthalmol CHN, 2019, 28: 325-327)

Key words: tuberculous uveitis/diagnosis, tuberculous uveitis/treatment