眼科

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39例拟诊结核性视网膜血管炎的临床特征

曹绪胜 李倩 呼风 彭晓燕   

  1. 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室 北京市眼科研究所
  • 收稿日期:2019-09-03 出版日期:2019-09-25 发布日期:2019-09-24
  • 通讯作者: 彭晓燕,Email: drpengxy@163.com
  • 基金资助:

    首都医科大学附属北京同仁医院重点医学专业发展计划(trzdyxzy201801)

Clinical features of 39 patients with presumed tubercular retinal vasculitis

CAO Xu-sheng, LI Qian, HU Feng, PENG Xiao-yan   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory Ophthalmology and Visual Science, Beijing Institute of Ophthalmology, Beijing 100730, China
  • Received:2019-09-03 Online:2019-09-25 Published:2019-09-24
  • Contact: PENG Xiao-yan, Email: drpengxy@163.com

摘要:

目的 探讨拟诊结核性视网膜血管炎的临床特征。设计 回顾性病例系列。研究对象 2013-2019年北京同仁医院眼科拟诊结核性视网膜血管炎患者39例(72眼)。方法 回顾患者的临床特征。主要指标 年龄、性别、全身结核感染史、视力受损原因、眼别、眼底、荧光素眼底血管造影和相干光断层成像的特征改变。结果 患者年龄(32.3±12.3)岁。男性33例(84.6%)。7例(17.9%)既往有结核感染病史,33例(84.6%)双眼受累。29例(38眼)因玻璃体积血致视力下降就诊,其中4例(5眼)已接受玻璃体切除和/或硅油填充术。彩色眼底照相或荧光素眼底血管造影检查可分辨眼底的62眼中,54眼(87.1%)呈闭塞性视网膜血管炎和/或继发视网膜新生血管,22眼(35.5%)黄斑水肿,15眼(24.2%)合并活动或稳定的斑片状脉络膜炎性病灶,9眼(14.5%)继发视网膜分支静脉阻塞。结论 男性、双眼发病、玻璃体积血、闭塞性视网膜血管炎和/或继发视网膜新生血管,黄斑水肿、斑片状脉络膜炎性病灶、继发视网膜分支静脉阻塞是拟诊结核性视网膜血管炎的常见临床特征。(眼科,2019, 28: 341-344)

关键词: 视网膜血管炎, 结核, 结核性葡萄膜炎

Abstract:

Objective To investigate the clinical features of presumed tubercular retinal vasculitis. Design Retrospective case series. Participants 39 consecutive patients (72 eyes) with presumed tubercular retinal vasculitis who consulted at the ophthalmic clinic of Beijing Tongren Hospital from June 2013 to June 2019. Methods We retrospectively reviewed the clinical features of the above-mentioned 39 patients (72 eyes). Main Outcome Measures Age, sex, systemic tuberculosis history, causes of visual impairment, laterality, the features of color fundus photography, fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). Results Mean age of the enrolled patients was 32.3±12.3 years. The patients were predominantly male (n=33/39; 84.6%). 7 patients (17.9%) had known history of systemic tuberculosis. A total of 33 patients (84.6%) had bilateral involvement. 29 patients (38 eyes) consulted at the clinic because of vitreous hemorrhage, 4 patients (5 eyes) of them had underwent pars plana vitrectomy and/or silicon oil injection. Among the 62 eyes which can be distinguished by color fundus photography and FFA, 54 eyes (87.1%) had occlusive type retinal vasculitis and/ or retinal neovascularization, 22 eyes (35.5%) had macular edema, 15 eyes (24.2%) had active or healed focal choroiditis lesions, 9 eyes (14.5%) had secondary branch retinal venous occlusion. Conclusions Male, bilateral involvement, vitreous hemorrhage, occlusive retinal vasculitis and/ or secondary retinal neovascularization, macular edema, focal choroiditis lesions, and secondary branch retinal venous occlusion are common clinical features of presumed tubercular retinal vasculitis. (Ophthalmol CHN, 2019, 28: 341-344)

Key words: retinal vasculitis, tuberculosis, tuberculous uveitis