眼科

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前节OCT观察明暗光线下眼前节静态参数及其动态变化的研究

吴若欣  李金瑛  柯瑞莉   

  1. 310013杭州,浙江医院眼科(吴若欣);518036深圳,北京大学深圳医院眼科(李金瑛、柯瑞莉)
  • 收稿日期:2017-01-03 出版日期:2017-07-25 发布日期:2017-07-24
  • 通讯作者: 李金瑛, Email:ljy951019@163.com

Ocular anterior segment parameters and the variations under light and dark conditions with AS-OCT 

WU Ruo-xin1, LI Jin-ying2, KE Rui-li2.   

  1. 1. Department of Ophthalmology, Zhejiang Hospital, Hangzhou 310013, China; 2. Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Received:2017-01-03 Online:2017-07-25 Published:2017-07-24
  • Contact: LI Jin-ying, Email: ljy951019@163.com

摘要:

 目的 评价原发性闭角型青光眼急性发作对侧眼、一般窄房角眼及正常眼在明、暗光线下眼前节静态参数及其动态变化的差异。设计 比较性病例系列。研究对象2013年5月至2015年5月在北京大学深圳医院、浙江医院眼科就诊的患者168例,临床前期组36眼、窄房角组120眼及正常宽角144眼。方法 应用 前节AS-OCT在明、暗光线下对入选眼进行检测,比较眼前节静态参数及明暗环境中动态变化的差异。主要指标 眼前节各参数,包括瞳孔直径(PD)、虹膜面积(IA)、房角开放距离(AOD)、房角开放度数(ACA)、小梁虹膜空间面积(TISA)、房角隐窝面积(ARA)等。结果 眼前节静态参数临床前期组与窄房角组差异无统计学意义。眼前节参数动态变化测量结果显示,从明处至暗处,即瞳孔散大时,窄房角组与临床前期组瞳孔直径变化值ΔPD均较正常宽角组小(P=0.002,0.011)。临床前期组虹膜面积增大(+5.83%), 而一般窄房角组虹膜面积则随瞳孔散大而减少(-3.50%),但不及正常宽角眼明显(-12.50%,P=0.004)。临床前期组与窄房角组相比,虹膜面积变化率(ΔIA%)及每毫米瞳孔散大时虹膜面积变化率(ΔIA%/ΔPD)差异具有统计学意义(P=0.036)。从明处至暗处,各组AOD、ACA、TISA、ARA均减小,但变化值无统计学差异。结论 仅有眼前节静态解剖参数的高危因素不能够有效识别发生房角关闭的高危窄房角眼。临床前期组与窄房角组瞳孔大小变化时相应虹膜横截面积变化可作为识别发生急性房角关闭高危眼的参考指标。(眼科, 2017, 26: 238-243)

关键词: 青光眼, 闭角型;眼前节相干光断层扫描

Abstract:

 Objective  To measure and evaluate ocular anterior segment static parameters and the dynamic changes in anterior chamber (AC) morphology under light and dark condition respectively in fellow eyes of acute angle-closure patients, the eyes with asymptomatic narrow angles(primary angle-closure suspects, PACS)  and normal open-angle eyes using anterior segment optical coherence tomography (AS-OCT). Design Comparative case series. Participants 36 fellow eyes of patients with acute angle closure; 120 PACS eyes; and 144 normal open-angle eyes from   Peking University Shenzhen Hospital and Zhejiang Hospital. Methods All the participants were imaged under light and dark conditions using AS-OCT. Main Outcome Measures  The anterior segment data from AS-OCT under light and dark conditions, include pupil diameter (PD), iris area (IA), angle open distance (AOD), anterior chamber angle (ACA), trabecular iris area (TISA), angle recess area (ArA). Results  The static anterior segment anatomic parameters did not differ significantly between the fellow eyes and the PACS eyes. When going from light to dark, the change of pupil diameter was more significant in the normal eyes than the fellow eyes and the PACS eyes. The mean iris area increased significantly in the fellow eyes (+5.83%), whereas it decreased in most PACS eyes (-3.50%), but not as significant as normal open angle eyes (-12.50%, P=0.004). The change rate of IA (IA%) and IA% per mm2 PD change (ΔIA%/ΔPD) differ significantly between the fellow eyes and the PACS eyes (P=0.036). The AOD, ACA, TISA and ARA decrease when going from light to dark, but the variations did not differ significantly between the two groups. Conclusion The static parameters alone had poor predictive power to identify eyes that will have the angle closure in future. The dynamic change of iris area in the fellow eyes and PACS eyes were significantly different. The abnormal dynamic behavior of the iris occurring in anatomically may predisposed eyes is a high risk of angle closure. (Ophthalmol CHN, 2017, 26: 238-243)

Key words: glaucoma, angle closure, anterior , segment optical coherence tomography