Ophthalmology in China

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The clinical characteristics and treatment of obital eosinophilic granuloma in children

ZHAO Shang-feng1, ZHANG Jia-liang1, SHI Ji-tong2, FU Ji-di1, LI Yong1, SUN Si1, WU Jiang-ping1, KANG Jun1   

  1. 1. Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; 2. Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
  • Received:2015-04-14 Online:2016-09-25 Published:2016-09-26
  • Contact: KANG Jun, Email: junkang2015@163.com


Objective To investigate the clinical manifestation and treatment of orbital eosinophilic granuloma(EG) in children.Design Retrospective case series. Participants 27 patients with orbital EG admitted into Beijing Tongren Hospital from March 2006 to February 2014 were enrolled. Methods These patients were all preoperatively evaluated with computed tomography(CT) and Magnetic Resonance Image(MRI). Surgical excision of the 1esions was performed and some cases were treated with chemotherapy postoperatively. The clinical charts and prognosis were analyzed. Main Outcome Measures Epidemiology, manifestation of CT and MRI, pathology characteristics and prognosis. Results The lesion involved the superior-lateral wall in 16 cases, orbital roof in 6 cases, lateral wall in 3 cases and both lateral wall and skull base in 2 cases. Total excision of the lesion was performed in all cases and the symptom disappeared. No complications occurred postoperatively. The dura and temporal muscle were found with infiltration of EG in 3 cases and 4 cases respectively. 4 cases received adjuvant chemotherapy after operation. No recurrence was noted during the follow-up examinations with a mean follow-up period of 2.36 years. Conclusions Orbital EG is a benign disease. Surgical resection is the most effective therapy. Adjuvant chemotherapy after surgery may be suggested. The overall prognosis for EG of the orbit is good. (Ophthalmol CHN, 2016, 25: 314-317)

Key words: eosinophilic granuloma, orbit, children