Ophthalmology in China

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The application of optical coherence tomography angiography in assessment of choroidal neovascularization secondary to pathologic myopia 

MO Jing1, ZENG Si-yan2, ZHOU Hai-ying1 , LI Zhi-hua1, WEI Wen-bin1.   

  1. 1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing 100730, China; 2. Department of Ophthalmology, Peking University Third Hospital. Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing 100191, China
  • Received:2019-06-22 Online:2019-07-25 Published:2019-07-30
  • Contact: WEI Wen-bin, Email: weiwenbintr@163.com


Objective To estimate the ability of OCTA in detecting choroiodal neovascularization (CNV) secondary to pathologic myopia and to assess the ability of OCTA in assessment of the activity of CNV compared to fundus fluorescein angiography (FFA). Design Diagnostic method evaluation. Participants 40 eyes with clinical diagnosis of CNV secondary to pathologic myopia in Beijing Tongren Eye Center. Methods All the eyes underwent FFA and OCTA respectively. The diagnosis of CNV and the judgment of CNV activity were compared between FFA and OCTA. Main Outcome Measures The sensitivity and specificity of OCTA, and Kappa value. Results The sensitivity and specificity of OCTA for choroidal neovascularization secondary to pathologic myopia were 96.7% and 100% respectively. The agreement for grading of CNV activity between OCTA and FFA was moderate (Kappa=0.502, P<0.001). Conclusion  OCTA demonstrate high sensitivity and specificity for detection of CNV secondary to pathological myopia, while with a moderate ability of grading CNV activity. (Ophthalmol CHN, 2019, 28: 265-268)

Key words: optical coherence tomography angiography, choroidal neovascularization, pathologic myopia