Ophthalmology in China

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Repeatability of quantitative assessment of the retinal microvasculature using optical coherence tomography angiography based on optical microangiography

ZHAO Qi1,  WANG Xiao-na1,  YANG Wen-li1,  WEI Wen-bin1,  WANG Ruikang K.12 , YOU Qi-sheng1,  CHU Zhong-di2,  XIN Chen1   

  1. 1. Beijing Institute of Ophthalmology,  Beijing Tongren Eye Center,  Beijing Tongren Hospital,  Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences,  Beijing 100730,  China; 2. Department of Bioengineering,  University of Washington,  Seattle 98195,  United States
  • Received:2017-11-21 Online:2018-03-25 Published:2018-03-24
  • Contact: YANG Wen-li, Email:yangwl_tr@163.com


Objective To determine the repeatability of optical coherence tomography angiography (OCTA) based on optical microangiography (OMAG) measurements of macular vessels in normal eyes. Design Diagnosis test. Participants A total of 40 eyes of 40 normal volunteers were examined at Beijing Tongren Eye Center. The mean age was 33.0±8.8 years (22~55 years). Methods OCTA data was acquired using Zeiss Cirrus HD-OCT 5000 angiography system. The following parameters were used for quantitative analysis:  vessel length density (VLD),  perfusion density (PD) and area,  perimeter,  circularity of foveal avascular zone (FAZ). Main Outcome Measures The coefficient of variation (CV) and intraclass correlation coefficients (ICC). Results All parameters showed high repeatability [CV(1.2±1.0)%~(4.2±5.5)%, all ≤4.2% (intravisit) and  (1.4±0.8)%~(4.6±4.9)%,  all≤4.6% (intervisit)] and interobserver reproducibility (ICC=0.923~0.994, all≥0.923). The CVs were higher for intervisit than for intravisit,  higher for fovea and FAZ than for parafovea. The ICCs were higher for fovea and FAZ than for parafovea. Conclusion The evidence presented here demonstrates good repeatability and reproducibility of OCTA based on OMAG for measurement of superficial vessel parameters in normal eyes.(Ophthalmol CHN,  2018, 27:107-110)

Key words: optical coherence tomography angiography, optical microgangiography, repeatability, retinal superficial capillary, vascular quantification