Abstract: Objective To evaluate MRI features of Mikulicz’s disease involving the lacrimal gland. Design Retrospective case series. Participants Twenty-four patients with Mikulicz’s disease involving the lacrimal gland confirmed by operation and pathology. Methods MRI findings of 24 cases with Mikulicz’s disease involving the lacrimal gland were retrospectively reviewed. MRI examination and contrast-enhanced imaging were performed in all patients and dynamic contrast-enhanced MRI was performed in 11 patients. Main Outcome Measures The MRI features of the lesion. Results In 24 cases, the lesion invaded bilateral lacrimal gland in 17 cases (70.8%), and unilateral in 7 cases. In the 7 cases, the lesion located in the left side in 5cases and right side in 2 cases. Compared with the brain gray matter, the lesion showed isointensity or hypointensity on T1WI and iso-, hypo- or hyperintensity on T2WI. After injection of the contrast medium, they showed moderately to significantly enhancement homogeniously. 11 cases who underwent dynamic contrast-enhanced MRI, a gradually enhancing pattern displayed in 2 cases and platform in 9 cases in time intensity curve. Moreover, the ocular muscles, corpus adiposum orbitae, infraorbital nerve and frontal nerve were involved in 8 cases (33.3%), 2 cases, 1 case and 5 cases respectively. Conclusion The MRI features of Mikulicz’s disease involving the lacrimal gland was enlargement of bilateral lacrimal gland diffusedly, and the involvement of trigeminal nerve, extraocular muscles and corpus adiposum orbitae. MRI can show the extent of the lesion clearly. (Ophthalmol CHN, 2014, 23: 47-50)

Key words: Mikulicz's disease, MRI, lacrimnal gland