Abstract: Objective To observe the relationship between the change of corneal biomechanical parameters and the measurement of intraocular pressure after LASIK. Design Prospective case series. Participants Eighty-one patients （162 eyes）with myopia were performed LASIK from Janurary to December in 2014 in the First Affiliated Hospital of Harbin Medical University. Methods  The corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated IOP value (IOPg) and corneal-compensated intraocular pressure (IOPcc) were examined with ocular response analyzer (ORA) before and after LASIK. The intraocular pressures were measure using non-contact tonometer (NCT) as well. Main Outcome Measures NCT，IOPcc，IOPg，CH，CRF before and after LASIK. Results Postoperative 3 months, CH , CRF , IOPcc, IOPg, and NCT measured values decreased significantly compared with those preoperatively. The comparison among IOPcc, IOPg and NCT postoperatively shows the significant distinction (P<0.05). There is a negative correlation between △CH , △CRF and △IOPcc , △IOPcc-IOPg and △IOPcc-△NCT. There is a positive correlation between △CH , △CRF and △IOPg and △NCT（P<0.05）. Conclusion The corneal biomechanics and the measurement of intraocular pressure after LASIK were lower than preoperatively. There is a correlation between the decline of the measurement of intraocular pressure and the decrement of CH and CRF. The level of intraocular pressure drop may be affected by corneal biomechanical properties.

Key words: IOP measurements, corneal biomechanical parameters, ocular response analyzer