Abstract:

Objective To study the effect of 1% topical atropine on the progression of myopia in the myopic astigmatism children. Design Case control study. Participants 120 cases (240 eyes) of highly myopic astigmatism (≥-1.50 diopter) children from 6 to 9 year old without amblyopia. Methods 120 (240 eyes) myopic astigmatism children were enrolled for the study, who were randomly divided into 3 groups, 40 cases (80 eyes) in each group. Group A was treated with glasses, group B was treated with glasses with compound tropicamide eye drops nightly, and group C was treated with 1% topical atropine gel every Friday evening combined with astigmatic glasses. The visual acuity, the status of refraction, the intraocular pressure and the axial length were examined monthly for 12 months. Main Outcome Measures Progression of myopic diopters and axial length. Results After 12 months, the progression of myopia in group C treated by 1% topical atropine gel every Friday evening combined with astigmatic glasses was significantly lower than group A and group B (F=58.031, P<0.001), and the increase of the axial length in group C was also significantly less than group A and group B (F=24.612, P<0.001). There was no significant reduction of astigmatic diopters among all groups (F=0.253, P=0.901). And there were no other complaints and complications such as high intraocular pressure and photophobia in children treated with 1% atropine gel. Conclusions It was a safe, effective resolution for most of high myopic astigmatism children treated with 1% topical atropine gel every Friday evening combined with astigmatic glasses for one year to slowdown the progression of myopia. （Ophthalmol CHN， 2016, 25： 298-301）

Key words: astigmatism, myopia, refraction, atropine, children