Abstract:

Objective To report the clinical ocular features of patients with Stevens- Johnson syndrome (SJS). Design Retrospective case series. Participants 90 eyes in 45 patients with a history of SJS and ocular involvement between August 2010 and June 2014 at Beijing Tongren Eye Center. Methods The clinical charactristics of 45 patients with a history of SJS were reviewed, and the data were analyzed with statistical software. Main Outcome Measures  The information collected for analysis included the ophthalmological history, visual acuity, adjunct treatments, and complications. Results A total of 45 patients (90 eyes) were recorded, 21 males (46.7%), with the average age of 28.0±20.2 years old. Average onset-treatment interval wsa 43.2±75.9 months. In the 90 affected eyes, 15 eyes (16.6%) were mild affected with an average BCVA LogMAR 0.55±0.91, 25 eyes (27.8%) were moderately affected with an average BCVA LogMAR 0.52±0.82, and 50 eyes (55.6%) were severely with an average BCVA LogMAR 1.33±1.05. Difference in BCVA between severe and other two groups were significant (P=0.038), and the differences of affected age and affected interval between severity groups had no statistical significance (P=0.47, 0.143 respectively). Sixty-eight eyes(75.6%) were complicated with dry eye disease, 63 eyes(66.7%) had cornea involvement, and 70 eyes (77.8%) experienced dysfunction of eyelids and meibomian glands. Conclusions SJS is potential vision threatening general disease. Severity of ocular surface lesion does not associated with age, gender, and duration. With careful patient care for secondary dry eye disease, eyelid abnormality and corneal neovascularization, reasonable life quality may frequently be achieved. (Ophthalmol CHN, 2016, 25: 382-386)

Key words: Stevens-Johnson syndrome/diagnosis, Stevens-Johnson syndrome/therapy