Ophthalmology in China

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Water drinking test influences intraocular pressure, axial length and choroid thickness in normal young adults

ZHANG Hui,HONG Jie, HUO Yan-jiao, WANG Huai-zhou, WANG Ning-li.   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Scince, Beijing 100730, China
  • Received:2016-07-24 Online:2017-01-25 Published:2017-01-20
  • Contact: WANG Ning-li, Email: wningli@vip.163.com


Objective To explore intraocular pressure (IOP), axis length and choroid thickness changes in healthy people after water drinking test. Design Cohort study. Participants Twenty eight young healthy volunteers with a mean age of 27.75 years. Methods Volunteers underwent water drinking test with drinking water 20 ml/kg in 5 minutes after 2 hours fasting. Measurements of choroidal thickness, IOP, and ocular biometry were taken before and after water drinking 10 min, 15 min, 30 min, 60 min. Enhanced Depth Imaging optical coherence tomography (EDI-OCT) was used to measure choroidal thickness at the fovea. IOP was measured by Goldmann applanation tonometry. Ocular biometric measures were collected using A scan ultrasound. The data of one eye of each volunteer were analyzed. Main Outcome Measures IOP, chroid thickness, axial length, anterior chamber depth, vitreous thickness, lens thickness. Results After water drinking 10 min, 15 min, 30 min, 60 min, the IOP was 14.51±2.60, 17.59±2.44, 17.19±2.78, 15.46±2.45 mmHg, respectively (P<0.001). After water drinking 30 min anterior chamber depth shallowed (P=0.04), after water drinking 60 min axial length shortened (P=0.02) and vitreous length thickness shortened (P=0.04). There was statistically significant difference. However, there was no significant difference in the mean choroidal thickness (P=0.935). Before water dringking and after water drinking 10 min, 15 min, 30 min, 60 min, the choroid thickness was 330.79±84.81, 340.00±91.97, 336.57±92.93, 334.86±85.63, 338.43±96.86 μm, respectively (P=0.935). Conclusion There is a significant increase in IOP from water drinking test. The axial length become shorter, the anterior chamber depth become shallow and the vitreous thickness become shorter, and the lens thickness and the choroid thickness have no significant changes. (Ophthalmol CHN, 2017, 26: 26-29)

Key words: water drinking test, intraocular pressure, chroid thickness, axial length