Ophthalmology in China

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Studies on Yiyangjianyin compound prescription in intervening guinea pig form deprivation myopia: eye living parameters measurements 

GAO Ran1,2, MA Dong-li1, LU Qing-jun1, LV Meng1, XIAN Jin-zhui1, PAN Mei-juan1.   

  1. 1. Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing 100730, China;  2. Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China
  • Received:2016-07-18 Online:2017-01-25 Published:2017-01-20
  • Contact: MA Dong-li, Email: madl888@163.com


 Objective To observe the effect of Yiyangjianyin compound prescription on eye living parameters of guinea pig form deprivation myopia. Design Experimental study. Participants 50 guinea pigs. Method Pigs were divided randomly into normal control group (group A), blank control group (group B), Yiyangjianyin compound prescription intervention group (group C), simple Yangyin compound prescription intervention group (group D). Both eyes of guinea pigs were not stitched up in group A, right eyes of guinea pigs were stitched up in group B, C, D to form deprived myopia model. There was no medicine intervention in Group B. Yiyangjianyin compound prescription intervention instead of water dinking was performed in Group C, and simple Yangyin prescription intervention instead of water drinking in Group D. Type-A ultrasonic was examined to measure eyeball parameters before experiments and after 6 weeks. Main Outcome Measures Vitreous chamber depth, axial length. Result The vitreous chamber depth (3.262±0.208) mm, axial length (7.687±0.256 mm) in Group C was significantly shorter than that of Group B (3.499±0.098) mm and (8.049±0.257) mm. The differences was statistical significance (all P<0.05). Vitreous chamber depth, axial length of right eye in four groups were compared in pairs. The difference was not statistical significance between Group A and C (all P>0.05), which showed the occurrence of deprivation myopia was not obvious in group C with the right eyelid suture. The differences of axial length was not statistical significance between right and left eyes within group C (P>0.05).  Conclusions Yiyangjianyin compound prescription can in some degree inhibit the development of guinea pig form deprivation myopia, which mainly delayed the deepening of vitreous chamber and lengthening of ocular axis.  (Ophthalmol CHN, 2017, 26: 44-48)

Key words: myopia, Yiyangjianyin therapeutic principle, Chinese traditional medicine intervention, animal experiment, guinea pig