Abstract:

Objective To explore the value of ^99mTc-diethylenetriaminepentaacetic acid (DTPA) SPECT/CT in evaluating the activity of thyroid associated ophthalmopathy(TAO). Design Retrospective case series. Participants 104 patients with TAO (191 afflicted eyes). Methods Orbital ^99mTc-DTPA SPECT/CT and the clinical activity score (CAS) were separately performed to patients. Main Outcome Measures The results of film-reading, the area of high uptake (N), an uptake radio between the posterior orbit and the occipital (URP), an uptake radio between the anterior orbit and the occipital (URA), and CAS. Results There were high uptake in active TAO, but low uptake or no uptake in inactive TAO. URP, URA, CAS in active TAO were significantly higher than those in inactive TAO according to the results of film-reading (P<0.001). URP, URA, N in active TAO were significantly higher than those in inactive TAO according to CAS (P<0.001). There was a positive correlation between URP, URA, N and CAS (r=0.47, 0.42, 0.55 respectively and all P<0.001). There was consistency between 99mTc-DTPA SPECT/CT and CAS (Kappa=0.37), but this consistency reduces in treated TAO. There were 54.7% of orbits with CAS<3 presenting high uptake, of which 97.9% orbits’ values were from 1 to 3. Conclusion As a complement to the CAS, ^99mTc-DTPA SPECT/CT has good clinical application value in evaluating the activity of TAO. (Ophthalmol CHN, 2018, 27: 344-348)

Key words: thyroid associated ophthalmopathy, diethylenetriaminepentaacetic acid, scintigraphy