Abstract:

Objective To explore the value of Bruch’s membrane opening-minimal rim width (BMO-MRW) in the identification of primary open angle glaucoma (POAG) and physical macrocup. Design Diagnostic technique evaluation. Participants Individuals underwent spectral domain optic coherence tomography (SD-OCT) in Beijing Tongren Hospital from April to May 2018 were selected and subdivided into normal control group (56 cases, 93 eyes), POAG group (55 cases, 89 eyes) and physical macrocup group (32 cases, 38 eyes). Methods Using SD-OCT radial scan mode, BMO-MRW was defined as the minimal width between Bruch’s membrane opening and internal limiting membrane (the vertical distance between Bruch’s membrane opening and internal limiting membrane). The BMO-MRW was measured in 12 quadrants with Heidelberg intrinsic softwere and were divided into superior, temporal, inferior and nasal quadrants. Main Outcome Measures Area under curve of receiver operator characterestics. Results BMO-MRW in superior, temporal, inferior, nasal quadrants was significantly smaller in POAG group (181.5±71.2, 133.8±55.0, 178.9±71.7, 180.9±78.4 μm) than in the physical macrocup group and control group (all P<0.001). POAG group showed significantly smaller BMO-MRW than physical macrocup group (all P<0.001). In receiver operator characteristics(ROC) analysis, area under curve (AUC) was 0.91±0.03 in inferior, 0.84±0.04 in superior, 0.79±0.04 in nasal and 0.72±0.05 in temporal. Conclusion BMO-MRW has important implications for evaluation and identification of physical macrocup and POAG.

Key words: primary open angle glaucoma, Bruch’s membrane opening-minimal rim width, physical macrocup