Abstract:

Objective To evaluate the effectiveness and safety of ab-interno microcatheter-assisted trabeculotomy in primary congenital glaucoma (PCG). Design Retrospective case series. Participants 27 cases (30 eyes) of PCG with transparent cornea from Beijing Tongren Eye Center in August 2018 to February 2019. Methods Ab-interno microcatheter-assisted trabeculotomy was performed in all patients. Patients were further divided into circumferential trabeculotomy group and partial trabeculotomy group, and without or with previous surgery group. The follow-up is 6 months. Main Outcome Measures IOP, numbers of antiglaucoma medications and postoperative complications. Results The mean baseline IOP was (31.5±6.1) mmHg on a median of 3（range: 1~4） medications. The mean IOP and numbers of antiglaucoma medications at the last follow-up was significantly reduced to (15.7±3.6) mmHg on a median of 0 (range 0~3) medications (both P<0.001). IOPs at baseline and last follow-up were both not significantly different between circumferential trabeculotomy group (17 eyes) and partial trabeculotomy group (13 eyes) (both P>0.05), while the IOP reduction was greater in circumferential trabeculotomy group (54.7%±10.1%) than that in partial trabeculotomy group (37.5%±16.8%，P=0.002). IOPs at baseline and last follow-up, and IOP reduction were all not significantly different between eyes without (16 eyes) or with (14 eyes) previous surgery (all P>0.05). Hyphema was seen in all eyes and 6 eyes (20%) had transient IOP spike in the early postoperative days. Conclusion The short-term follow-up shows that ab-interno microcatheter-assisted trabeculotomy is feasible for the treatment of primary congenital glaucoma with transparent cornea.

Key words: ab-interno microcatheter-assisted trabeculotomy; , primary congenital glaucoma