Ophthalmology in China

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Clinical histopathologic constituent analysis of 167 cases of ciliary body mass treated by local resection from 2010 to 2019

Gao Fei, Xu Xiaolin, Zhang Xu, Zhang Zhibao, Wei Wenbin   

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
  • Received:2020-06-06 Online:2020-09-25 Published:2020-09-25
  • Contact: Xu Xiaolin, Email: drxuxiaolin@163.com
  • Supported by:
    National Natural Science Foundation of China (81502341), Natural Science Foundation of Beijing (7151003)

Abstract: Objective To analyze the clinical histopathologic constituent of 167 cases of ciliary body mass treated by local resection. Design Retrospective case series. Participants 167 ciliary body masses treated by local resection in Beijing Tongren Hospital in 2010-2019. Methods The pathological records of ciliary body masses were reviewed retrospectively to record the general clinical information and pathological diagnosis. The constituent ratio of the histopathologic types of ciliary body masses was calculated. Main Outcome Measures The constituent ratio of the histopathologic types. Results This group of 167 ciliary body masses were arranged in order of constituent ratio: 44 cases of melanocytoma (26.3%), 32/2 cases of nonpigmented epithelium adenoma/adenocarcinoma (20.4%), 29 cases of melanoma (17.4%), 14 cases of schwannoma (8.4%), 12 cases of leiomyoma (7.2%), 11 cases of glioneuroma (6.6%), 9 cases of medulloepithelioma (5.4%), 7 cases of pigmented epithelium adenoma (4.2%), 2 cases of hemangioma (1.2%), 2 cases of inflammation(1.2%), nevus, lymphoma and granular cell lesion 1 case (0.6%) each. Malignant lesions accounted for 24.6% (41/167) and benign lesions accounted for 75.4% (126/167). Masses originated from ciliary body epithelial layer accounted for slightly more than a third (36.5%), and masses originated from ciliary body stroma accounted for slightly less than two thirds (63.5%). The top three of epithelial layer originated masses were nonpigmented epithelium adenoma, medulloepithelioma, pigmented epithelium adenoma. The top three of stroma originated masses were melanocytoma, melanoma, and schwannoma. The number of pigmented masses and nonpigmented masses was equal (49.7% and 50.3%). The top three of pigmented masses were melanocytoma, melanoma and pigmented epithelium adenoma. The top three of nonpigmented masses were nonpigmented epithelium adenoma, schwannoma and leiomyoma. Conclusion In this group of ciliary body masses, the top three histopathologic types were melanocytoma, nonpigmented epithelium adenoma and melanoma. On the whole, malignancy accounted for a small proportion, close to a quarter, suggesting that we should give priority to local resection of the mass, when choosing the treatment scheme, and cannot easily carry out enucleation. (Ophthalmol CHN, 2020, 29: 391-395)

Key words: eye neoplasms/pathology, ciliary body