Abstract: Myopic foveoschisis (MF) is the most common macular disease that causes visual impairment in patients with high myopia, and can be followed by a variety of serious fundus diseases, such as macular hole, macular hole retinal detachment and so on. At present, the management strategies of MF are various. Although vitrectomy is standard treatment for MF, the reports of posterior scleral reinforcement are increasing in recent years. The pathogenesis of MF is mostly chronic and progressive. The difficulty of clinical trial is that patients are often scattered and lack of consultation and treatment. The clinical manifestations of MF are various, including the range of MF involvement, the height of retinal schisis, whether combined with epiretinal membrane and posterior vitreous detachment, the degree of adhesion of posterior vitreous cortex etc. To deal with various manifestations, we need corresponding research evidence, which is still relatively superficial at present. In addition to carrying out randomized controlled trials, it is a new hope to carry out real world study in the era of big data for the treatment of MF.

Key words: myopic foveoschisis, multicenter randomized controlled trial, real world study