Abstract: Objective To investigate the clinical characteristics and treatment of eyelid granuloma after autologous fat facial filling. Design Retrospective case series. Participants From August 2017 to December 2020, 9 patients (11 eyes) with orbital granuloma caused by autologous fat facial filling were collected from the Beijing Tongren Eye Center. Methods The sex, age, eye type of onset, location of eyelid mass, symptoms, clinical manifestations, location of autologous fat transplantation, time from autologous fat transplantation to eyelid mass, characteristics of imaging examination, treatment methods and therapeutic effects, and the results of pathological examination were collated and described, the follow-up period was 6 months. Main Outcome Measures Clinical characteristics, treatment, and efficacy. Results All patients were female, aged from 25 to 51 years old, with an average age 36.33±8.86 years old. Two patients had binocular involvement (22.2%) and 7 patients had monocular involvement (77.8%), including 2 cases in the right eye (22.2%) and 5 cases in the left eye (55.6%). Both upper and lower eyelids were involved in 1 patient (11.1%), upper eyelid in 5 patients (55.6%), lower eyelid in 3 patients (33.3%). The patient's eyelids were slightly red, swollen and painful, and the eyelids can touch a lump, and 2 patients were associated with ptosis. 3 patients received oral methylprednisolone, the tumor became smaller obviously and was not completely absorbed after 6 months. One patient received local injection of triamcinolone acetonide，the tumor became smaller obviously after 1 month, and the lower eyelid did not touch the tumor after 6 months. 3 patients underwent surgical resection of lipogranuloma. Histopathology showed the characteristics of lipogranuloma reaction, foreign body giant cells gathered around lipid-rich microcapsules of different sizes. No recurrence was found after follow-up for 6 months. 1 patient received ultrashort wave and laser physiotherapy, the inflammation subsided and the tumor decreased. The boundary gradually became clear, but there was a relapse after the cessation of physiotherapy. 1 patient refused operation and medicine because the tumor was small, and was observed regularly. Conclusion Facial injection of autologous fat can lead to a delayed benign lesion in the orbital region, the fat granuloma. and surgical resection can be taken when observation and drug conservative treatment are ineffective. (Ophthalmol CHN, 2021, 30: 204-209)

Key words: lipogranuloma, autologous fat injection, eyelid mass