Abstract: Objective To investigated the association of diabetic macular edema (DME) with the impaired renal function in a sample of patients with type 2 diabetes. Design Retrospective case series. Participants A total of 1023 patients with type 2 diabetes hospitalized in the Endocrinology Department of Beijing Geriatric Hospital, who were consulted in ophthalmology, from Jan 2016 to Dec 2020. Methods Age, blood pressure, serum creatinine, fasting venous blood glucose, glycosylated hemoglobin and urinary microalbumin were obtained by reviewing the medical records. Estimated glomerular fifiltration rate (eGFR) was assessed using the CKD-EPI formula and graded (normal renal function ≥ 90 mL/min/1.73 m2; impaired renal function, 60~89 mL/min/1.73 m2; and renal inadequacy < 60 mL/min/1.73 m2). Stereoscopic color fundus image and optical coherence tomography image were also reviewed. DME was confirmed according to standard of Early Treatment Diabetic Retinopathy Study. The correlation between stage of eGFR and presence of DME was assessed by Logistic regression. Main Outcome Measures The presence of DME in different eGFR group. Results Of the 1023 patients with type 2 diabetes included, 120 patients had DME. In patients with normal, impaired and impaired renal function, the presence of DME were 8.30%, 20.51% and 24.63% (χ2=34.252, P=0.000). Logistic regression showed that the risk of DME in patients with impaired renal function and renal insufficiency was 1.604 and 2.573 times higher than those with normal renal function. Conclusion DME is associated with impaired renal function and its severity. (Ophthalmol CHN, 2021, 30: 232-235)

Key words: diabetic macular edema, estimated glomerular filtration rate, type 2 diabetes