Abstract: Objective To investigate the characteristics of ophthalmic manifestation of patients with neurosyphilis. Design Retrospective case series. Participants 141 cases (282 eyes) of neurosyphilis patients admitted to Beijing Ditan Hospital in 2016-2019. Methods Medical records of all patients data were reviewed, including best corrected visual acuity, slit lamp, intraocular pressure, ocular position, eye movement and fundus examination. Clinical manifestations and imaging characteristics of patients were reviewed. Main Outcome Measures Best corrected visual acuity, pupil, optic nerve, retinal choroidal changes and neuropathy associated with ocular movement. Results In all 141 cases (282 eyes), 74 cases(52.5%)(127 eyes) had ocular manifestations, of which pupil abnormalities (43.3%) were the most common, including Argyll-Robertson pupil was the only clinical manifestation in 18 cases (33 eyes) and Adie pupil was the only clinical manifestation in 6 cases (8 eyes). 35 cases(24.8%) (61 eyes) expressed as uveitis and ophthalmoplegia was found in 7 cases (5.0%) (8 eyes). 6 cases (4.3%) (11 eyes) expressed as optic neuropathy. Syphilitic scleritis was found in 2 cases (1.4%) (2 eyes). Conclusion The characteristics of ophthalmic manifestation of patients with neurosyphilis are various. The common manifestations are pupil change and uveitis involving optic nerve. (Ophthalmol CHN, 2021, 30: 386-390)

Key words: neurosyphilis, eye infections