Abstract: Objective To compare the visual quality between wavefront-guided ablation and topography-guided ablation in femtosecond laser-assisted in situ keratomileusis (FS-LASIK) for myopia. Design Retrospective case series. Participants 130 myopia patients (130 eyes) received FS-LASIK in Beijing Tongren Hospital. Methods 68 myopic patients underwent wavefront-guided customized FS-LASIK (wavefront-guided group) and 62 myopic patients underwent topography-guided FS-LASIK (topography-guided group) were reviewed. Only the right eye data from each patient was analyzed. Visual quality outcomes preoperatively and 6 months postoperatively were compared between groups. Main Outcome Measures Visual acuity, higher order aberrations (HOAs) and contrast sensitivity (CS). Results The uncorrected visual acuity (UCVA) levels after surgery reached or superior to the preoperative best corrected visual acuity (BCVA) were in 94.1% patients in the wavefront-guided group and in 95.2% patients in the topography-guided group 6 months after surgery, respectively (χ2=0.069, P>0.05). There is no significant difference in Log contrast sensitivity (LogCS) values between groups (all P>0.05). There are no significant differences in the amount of changes in the higher order aberrations between the two groups (all P>0.05). Conclusion Both wavefront aberration guided FS-LASIK and corneal topography guided FS-LASIK can obtain good visual acuity and visual quality after surgery. (Ophthalmol CHN, 2022, 31: 57-62)

Key words: laser in situ keratomileusis, visual qualiy