Ophthalmology in China ›› 2022, Vol. 31 ›› Issue (4): 260-265.doi: 10.13281/j.cnki.issn.1004-4469.2022.04.003

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Relationship between retinal arteriosclerosis grading and predicted 10-year risks of cardiovascular disease (China-PAR Equations) in a community-based population in Beijing

She Haicheng1, Yan Shenshen1, Sun Pengfei2, Fan Fangfang2, 3, Jiang Yimeng2, Jia Jia2, 3, Liu Bo2, Zhou Jinqiang1, Zhang Yan2, 3#br#

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  1. 1 Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; 2 Department of Cardiology, Peking University First Hospital, Beijing 100034, China; 3 Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China

  • Received:2022-05-05 Online:2022-07-25 Published:2022-07-29
  • Contact: Zhang Yan, Email: drzhy1108@vip.163.com
  • Supported by:
    Capital’s Funds for Health Improvement and Research (2020-2-2053); UMHS-PUHSC Joint Institute for Translational and Clinical Research and the Fundamental Research Funds for the Central Universities (BMU20110177, BMU20160530); National Key Research and Development Program of China (2017YFC1307704); Chinese Cardiovascular Association-Access Fund (2019-CCA-ACCESS-112); The Priming Scientific Research Foundation for the Junior Researcher in Beijing Tongren Hospital, Capital Medical University (2018-YJJ-ZZL-031)

Abstract: Objective To explore the relationship between retinal arteriosclerosis grading and China-PAR model in predicting10-year cardiovascular disease (CVD) risk in a Beijing community. Design Cross-sectional study. Participants The subjects were from the atherosclerosis research cohort in Shijingshan community, Beijing. This study was a cross-sectional study followed up from December 2019 to January 2020. A total of 673 participants who had no history of cardiovascular disease, with complete questionnaire data and fundus photograph were finally included. Methods The degree of retinal arteriosclerosis was graded according to the Scheie’s classification. Multivariate Logistic regression was used to analyze the relationship between retinal arteriosclerosis grading and 10-year CVD risk, and further adjustment including hypoglycemic drugs, lipid-lowering drugs and estimated glomerular filtration rate (eGFR) was made. Main Outcome Measures 10-year CVD risk calculated by China-PAR model. Results The subjects were 61.9±7.4 years old and 422(62.7%) were women . Of all the subjects, 53.0% (n=357) had hypertension, 78.0% (n=525) had dyslipidemia, 30.5% (n=205) had diabetes and 23.5% (n=158) had a family history of CVD. The percentage of subjects with grad 0-1, grad 2 and grade 3-4 arteriosclerosis were 57.1% (n=384), 37.3% (n=251) and 5.6% (n=38), respectively. Of the10-year CVD risk calculated by China-PAR model, 209 (31.1%) subjects were at low risk, 206 subjects (31.1%) were at medium risk and 258 (38.3%) subjects were at high risk. Multivariate regression analysis showed that the retinal arteriosclerosis grading was positively correlated with the10-year risk of CVD. Compared with grade 0-1 retinal arteriosclerosis, the risk ratio of medium risk CVD increased by 52% (OR=1.52, 95%CI: 1.00~2.31, P=0.048) in grade 2 retinal arteriosclerosis; and the risk ratio of high risk CVD increased by 92% (OR=1.92, 95%CI: 1.24~2.96, P=0.003) in grade 2 retinal arteriosclerosis. Compared with grade 0-1 retinal arteriosclerosis, the risk ratio of medium risk CVD increased by 6.47 times (OR=7.47, 95%CI: 1.62~34.52, P=0.010) in grade 3-4 retinal arteriosclerosis; and the risk ratio of high risk CVD increased by 7.62 times (OR=8.62, 95%CI: 1.87~39.69, P=0.006) in grade 3-4 retinal arteriosclerosis. Conclusion The grade of retinal arteriosclerosis is significantly correlated with the 10-year CVD risk predicted by China-PAR model. The heavier the degree of retinal arteriosclerosis , the higher risk of predicted 10-year CVD risk. （Ophthalmol CHN, 2022, 31: 260-265）


Key words: arteriosclerosis, cardiovascular disease, risk prediction, China-PAR equation