Abstract: Objective To explore the application effect of lacrimal irrigation needle combined with meibomian gland clip in the excision of localized pigmented nevus on the eyelid margin of inner canthus. Design Retrospective non-comparative case series. Participants 16 patients (16 eyes) with localized pigmented nevus of eyelid margin in inner canthus were collected in Beijing Tongren Hospital from 2017 to 2021. Methods All cases were resected under microscope, and the pigmented nevus of eyelid margin was fixed with meibomian gland clip. The position of lacrimal passage and its adjacent relationship with pigmented nevus on eyelid margin with the aid of lacrimal passage irrigation needle inserted into lacrimal passage were observed. Conjunctival surface defect was treated with not repaired method, and eyelid anterior layer defect was repaired with skin transposition flap. Main Outcome Measures Situation of postoperative lacrimal passage, eyelid position and appearance. Results The average postoperative follow-up period was 8±1.5 months. 16 patients had clear visual field and less bleeding during surgery. At last follow-up, all 16 patients had no epiphora and the lower eyelid lacrimal passage was smooth. There was no obvious scar, angular deformity, eyelid entropion, ectropion, punctum atresia, and no recurrence of pigmented nevus at eyelid margin. Conclusions Using lacrimal irrigation needle and meibomian gland clip during surgery of localized pigmented nevus of the inner canthus can got effect of clear visual field and good hemostasis. It can also protect the lacrimal passage from injury. (Ophthalmol CHN, 2022, 31: 312-314)