Abstract:  Abnormally high intraocular pressure is the most significant risk factor for primary open-angle glaucoma(POAG). The clinical model of glaucoma treatment using intraocular pressure as the target has long been used. Various systemic risk factors such as circulating factors, body mass index, intracranial pressure, nutritional metabolism, constiturion types as defined by traditichal Chinese medicine, and some systemic diseases have been found to be related to glaucoma onset, progression and regression, and are being tried to be applied as new therapeutic targets for optic nerve protection treatment of glaucoma. This manuscript aims to provide an overview,  on systemic risk factors of POAG, to advocate glaucoma doctors to pay attention to systemic risk factors and to build a new glaucoma diagnosis and treatment system combining systemic risk factor assessment and personalized ocular and physical co-treatment. (Ophthalmol CHN, 2022, 31: 325-329)

Key words: primary open-angle glaucoma, risk factors