Abstract: Objective To investigate short-term clinical effects of infant patients with persistent fetal vasculature (PFV) with complicated anterior segment anamolies, treated by lensectomy combined with vitrectomy through corneal incisions. Design Retrospective case series. Participants Patients diagnosed with PFV with complicated anterior segment anamolies, and underwent lensectomy combined with vitrectomy through corneal incisions in Beijing Tongren hospital from May 2019 to January 2022 were studied. Seventeen patients (17 eyes) including 10 males, with an average age of (13.4±9.2) months were included. Methods The clinical data of the patients were retrospectively described. Pre- and postoperative visual acuity and postoperative complications were observed. Main Outcome Measures Visual acuity, changes of opacity of the optical media of the pupillary zone and postoperative complications. Results At last visit, 9 of the 12 patients had postoperative fix and follow ability of visual acuity improvement compared with that of preoperative, None patients had clear optical media of the pupillary zone preoperatively, and all the 17 patients had clear optic media postoperatively; 4 eyes complicated with postoperative recurrent pupil membrane formation, which needed further operation; no cases with intraoperative or postoperative intraocular hemorrhage, secondary retinal detachment or ophthalmitis were observed. Conclusion Infants with PFV complicated anterior segment anamolies may have optimistic visual and anatomical prognosis after surgical treatment of lensectomy combined with vitrectomy through corneal incisions. (Ophthalmol CHN, 2022, 31: 360-363)

Key words: persistent fetal vasculature/surgery, infant