Abstract: Objective To analyze the clinical features of uveitis-glaucoma-hyphema (UGH) syndrome. Design Retrospective case series. Participants 8 patients (8 eyes) diagnosed with UGH syndrome in the Eye Hospital affiliated to Shandong University of Traditional Chinese Medicine from 2018 to 2022. Methods The clinical data of 8 patients with UGH syndrome were reviewed and the clinical characteristics, treatment and prognosis were sumarized. Main Outcome Measures Clinical characteristics and imaging findings. Results 8 UGH syndrome patients were attack from 1 to 6 months after IOL implantation. The average IOP was (42.91±11.54) mmHg, and there were different degrees of anterior chamber flare in all patients, 4 cases had hyphema and 4 cases had red blood cells on the aqueous smear. All cases had IOL deviation and contaction with iris and ciliary body. 2 cases of posterior concave of iris demenstrate IOL contactiont with posterior surface of iris. 4 cases exist IOL deviation and contact with posterior surface of iris. 1 case exists contact with ciliary body. One case was treated with drugs, two cases with posterior fovea of iris were treated with YAG laser iridotomy. One case each was treated with IOL repositioning, IOL replacement, IOL removal, glaucoma valve implantation, and ciliary body photocoagulation. All patients were followed up for 6 to 46 months after treatment. The anterior chamber flare and red blood cells in the anterior chamber disappeared, and the IOL contacting with the iris and ciliary body disappeared. Conclusion The clinical features of UGH syndrome are IOL contacting with iris or ciliary body after cataract surgery, high IOP, anterior chamber flare and red blood cells existing in the anterior chamber. Its treatment is to relieve the friction between IOL and iris or ciliary body. (Ophthalmol CHN, 2023, 32: 127-132)

Key words: uveitis-glaucoma-hyphema syndrome, clinical features