Abstract:  Vitreoretinal interface consists of posterior vitreous cortex, retina internal limiting membrane, and extracellular matrix. Basement membrane-like complex is formed in the interface, especially in some special locations, such as vitreous base, optic disc margin, retinal vessels, macular foveola, and some pathologic lesions. With aging, the posterior margin of vitreous base extends posteriorly, internal limiting membrane thickens and its elasticity decreases, the adhesion in vitreoretinal interface weakens, and posterior vitreous detachment develops. To fully recognize the interface and its age-related changes is of much importance for understanding the pathophysiology and treatment strategy of some diseases. (Ophthalmol CHN, 2023, 32: 265-274)

Key words:  , posterior vitreous cortex, internal limiting membrane, vitreretinal interface