Abstract:  Objective  To observe the therapeutic effect of sensory perceptual learning for anisometropic amblyopia in children.  Design  Prospective study. Participants 124 eyes in 74 children aged from 4 to 12 were diagnosed as anisometropic amblyopia from 2008 to 2010 in Beijing Children’s Hospital. Methods The participants were examined with visual processing information test, including noise acuity, positional noise, contour integration and high-level deficit test. According to the test results, the individual treatment prescription was chosed.  The treatment was performed twice a day, 30 minutes per time. Three months was a stage. The patients were rechecked per month and the treatment prescription were adjusted according to the results. The therapeutic effect was assessed. Cured means visual acuity was improved to 0.9  or more after treatment; improved means visual acuity was improved 2 lines or more; invalid means visual acuity was no improved or improved 1 line only.  Main Outcome Measures Visual acuity, visual processing information test, including noise acuity, positional noise, contour integration and high-level deficit test. Results  124 eyes of 74 children were treated for 4~12 months, average 6.8 months. 44 eyes (35.48%) were cured, 52 eyes (41.94%) were improved, 28 eyes (22.58%) were invalid. Noise acuity was enhanced (0.85~4.27), positional noise (0.80~1.32) and contour integration (0.62~1.27) were all improved. No visual acuity decline and other adverse reactions were observed. Conclusion The sensory perceptual learning is a good compliance treatment for anisometropic amblyopia, which can improve the pateint's visual acuity and visual function.

Key words: perceptual learning, anisometropia, amblyopia, contour integration, children