Abstract: Objective To analyze the safety of implantation of posterior chamber phakic refractive lens （PC-PRL） for high myopia. Design Retrospective case series. Participants Sixty-eight eyes of 35 cases with high myopia who were implanted PC-PRL in Beijing Tongren Hospital from Jul. 2006 to Sep. 2007. Methods Type of PC-PRL was selected according to the distance of white to white and the refractive power. After PC-PRL was implanted, visual acuity, refraction, intraocular pressure and corneal endothelium count were measured at the last follow-up. The follow-up time was 43 to 57 months. Main Outcome Measures Visual acuity, refractive power, intraocular pressure, corneal endothelium count, the distance from PC-PRL to cornea and lens, and the complications. Results At the last follow-up, the uncorrected visiual acuity was equaled to the best corrected visiual acuity (BCVA) before surgery in 85.29% (58/68) eyes. The post-operative BCVA even was better than the BCVA before surgery in 35.29% (24/68) eyes. The mean intraocular pressure was 17.1±2.6 mm Hg. Corneal endothelium cell counts showed 2841±257 /mm2 before surgery and 2512±312 /mm2 after surgery (t=0.872, P=0.160). At the last follow-up, the distance from anterior surface of PC-PRL to corneal endothelium was 2.341±0.258 mm, compared with 2.491±0.317 mm at three months after surgery, there was no significant difference (t=1.407, P=0.076); the distance from posterior surface of PC-PRL to lens was 0.302±0.109 mm, also showed no significant difference from that was at 3 months after surgery （0.321±0.102） mm (t=1.516, P=0.064). Two cases (2 eyes) were found whose posterior surface of PC-PRL contacted with anterior surface of lens, the distance was too small to be measured. The complications, such as glaucoma, retina detachment, and complicated cataract, were not observed in all surgical eyes. Conclusion Implantation of PC-PRL can correct high myopia effectively. The long term safety of PC-PRL should be observed, especially the influence to lens.

Key words: posterior chamber phakic intraocular lens/complication, high myopia/surgery