Abstract: Objective To investigate the clinical applications of spectral domain-optical coherence tomography (SD-OCT) in the central serous chorioretinophthy (CSC) and to analyze the relation between the visual acuity and measurements of the serous detachment of CSC. Design Retrospective case series. Participants Thirty-seven eyes of 34 patients with CSC in Tongji hospital from Nov. 2010 to March. 2011. Methods All patients were examined with Spectralis OCT. Retinal morphological features were observed. The macular retinal thickness and volume at 1, 3, and 6 mm (9 partitions) were measured with macular topographic map analysis software. Then the serous detachment height and detachment width were measured manually. Finally, we use SPSS17.0 software to analyze the correlation of  the measurements with the vision.  Main Outcome Measures The retinal morphological features, the macular retinal thickness and volume at 1, 3, 6 mm (9 partitions), the serous detachment height and detachment width, and visual acuity. Results Images from SD-OCT showed the pure nerve layer detachment in 22 eyes, the nerve layer detachment merged with retinal pigment epithelium detachment (PED) in 13 eyes, and no detachment in 2 eyes;  Statistical analysis shows that the correlations between the vision and inspected parameters were different. There were significant correlation between the visions and the retina thickness，the volume at 1 mm, the serous detachment height and the detachment width (r=-0.406, -0.405, -0.438, -0.389, P all<0.05); between the visions and the retina thickness at four partitions, the volume at the nasal , the temporal partition in 3mm (r=-0.481, -0.462, -0.332, -0.358, -0.461, -0.357, P all <0.05); between the visions and the retina thickness at the nasal, the above partition, and the volume at 6 mm (r=-0.428, -0.466, -0.429, -0.468, P all <0.01). The volume of the above, the below partition at 3 mm and the thickness and volume of the temporal, the below partition at 6 mm had a little correlation with the visions(P all >0.05); the vision of pure nerve layer detachment group (0.50±0.26) was not significantly different from that of the nerve layer detachment merged with PED group (0.48±0.15) (P= 0.759). Conclusion SD-OCT can provide noninvasive inspection to patients with CSC, it can not only identify the change of the retinal tissue but also offer the quantitative tracking observation and assist the effect assessment, which is helpful to follow up condition changes and predict the prognosis.

Key words: central serous chorioretinopathy, SD-optical coherence tomography, visual acuity, tomography, optical coherence