Abstract:  Objective To study the prevalence of glaucoma-like optic neuropathy with sellar tumors. Design Retrospective control study. Participants 501 patients diagnosed with sellar tumor from year 2008 to 2009 in Beijing Tiantan Hospital were chosen consecutively. Methods All the patients had undergone fundus photography and automatic visual field examination.  A total of 454 age-matched controls were randomly chosen from the population-based Beijing Eye Study.  The type and size of the tumors were assessed on neuroradiological images(MRI). Main Outcome Measures Prevalence of glaucoma-like optic neuropathy in tumor group and control group, and its associations. Results The prevalence of glaucoma-like optic neuropathy was 6.8%(34 cases) (disc-glaucoma) and 6.3%(31 cases) (field-glaucoma), which was significantly more frequent than that in the population-based control group of the same ethnicity (1.3%; P<0.001). In multivariate analysis, the presence of glaucoma-like optic neuropathy was significantly associated with tumor location (suprasellar > parasellar > intrasellar, P=0.010 and P=0.001) and tumor width (P=0.003).  Conclusions The prevalence of glaucoma-like optic neuropathy in sellar tumor patients was higher than that of population-based control group. Glaucoma-like optic neuropathy in sellar tumors patients was associated with tumor width and tumor location. （Ophthalmol CHN, 2012, 21: 302-305）

Key words: sellar tumors, glaucoma-like optic neuropathy