Abstract:  Objective To measure and compare anterior scleral thickness in fellow eyes of acute primary angle-closure glaucoma (APACG) and in normal eyes. Design Prospective comparative case series. Participants Fifty seven fellow eyes of 57 patients with APACG and 57 normal eyes were enrolled. Methods Anterior sclera thickness (ST) and center corneal thickness (CCT) were measured with ultrasound biomicroscopy (UBM), and the images were obtained by a same examiner scanning the center corneal area and temporal corneoscleral limbus. ST was measured at 2.0 mm posterior to scleral spur. Axis length was measured with IOL Master. Intraocular pressure (IOP) was measured with non-contact tonometer.  T test was performed, and multiple linear regressions were performed between anterior sclera thickness and other parameters. Main Outcome Measures IOP, CCT, anterior ST and axis length. Results In fellow eyes of APACG and in normal subjects, the mean anterior ST was (625.42±41.45) ?滋m, (594.42±46.06) ?滋m respectively (t=3.78, P=0.0001); the mean IOP was (16.70±3.75),  (17.00±3.92) mm Hg respectively (t=0.42, P=0.338); the mean CCT was(537.08±34.68) ?滋m,(529.90±39.69) ?滋m respectively (t=1.03, P=0.153); the mean axis length was(20.78±1.23), (23.56±2.21) mm respectively (t=8.30, P=0.000). Multiple linear regression showed that in fellow eyes of APACG, the relationship between anterior ST and ocular axis had statistic significant (P=0.0090). Equation is Y (anterior ST) =877.144-12.135× (ocular axis ). Conclusion The thicker anterior sclera might be related to the acute episode of APACG attacks. (Ophthalmol CHN, 2013, 22: 249-252)

Key words: acute primary angle-closure glaucoma, scleral thickness