Ophthalmology in China ›› 2013, Vol. 22 ›› Issue (5): 332-334.

Previous Articles     Next Articles

The effect of levobunolol on anterior corneal surface curvature after Laser in-situ keratomileusis

 WU  Gui-Ling, HU  Qi, WU  Qiong, YANG  Fan, WANG  Ke-Meng   

  1. The Optometry and Ophthalmology Department of Eye Hospital, the First Affiliated Hospital of Harbin Medical University,  Harbin 150001, China
  • Received:2012-12-13 Online:2013-09-25 Published:2013-09-29
  • Contact: HU Qi, Email: huqi5115@sina.com

Abstract: Objective To compare the effect of levobunolol hydrochloride eye drops on anterior corneal surface curvature applied in different stage after laser in-situ keratomileusis, to infer the effect of IOP-lowing medication on anterior corneal surface after laser in-situ keratomilersis. Design Case control study. Participants 111 cases (197 eyes) who were treated by laser in-situ keratomileusis and continuously followed up, the diopter of whom before operation was -6.00~-9.00 D. Methods 111 cases (197eyes) were randomly divided into 3 groups. Treatment group I (77 eyes) was treated by levobunolol hydrochloride eye drops from the first day after laser in-situ keratomileusis. Treatment group II (46 eyes) was treated by levobunolol hydrochloride eye drops from the fourteenth day after laser in-situ keratomileusis. Control group (74 eyes) was regularly treated. The anterior corneal surface curvatures were measured before and 3 months after operation and compared between groups. IOP were measured before operation and 1 month, 3 months after operation and compared between groups. Main Outcome Measures The anterior corneal surface curvature. Results The average of the differences between preoperative and postoperative anterior corneal surface curvatures were (6.51±0.91)D in the treatment group I, (6.24±0.96)D in the treatment group II and (6.19±1.02)D in the control group, respectively.  The difference between the treatment group I and the control group was significant (F=4.04, P=0.045), the difference between the treatment group II and the control group was insignificant (F=0.02, P=0.760), the difference between the treatment group I and the treatment group II was insignificant (F=2.27, P=0.148). Conclusion Levobunolol hydrochloride eye drops applied in the early stage after laser in-situ keratomileusis is beneficial to the stability of anterior corneal surface. (Ophthalmology CHN, 2013, 22: 332-334)

Key words: levobunolol hydrochloride, laser in situ keratomileusis ( LASIK ), anterior corneal surface curvature