Abstract: Objective To evaluate the effectiveness in regards to new treatment's substantial improvements in patients' instillation accuracy and avoid potential drug exposure infection. Design Prospective case-control study. Participants 27 numbers of patients receiving treatment from Ophthalmology Department ward of Beijing Tongren Hospital, between November 2007 and December 2007. Method Patients with single eye in trouble belong to “patient team”; patients without eye problem belong to “regular team”. For patients with problems in both eyes, the weaker-sighted eye should belong to “patient team”. Arrange the above chosen patients to test the whole process of new method of eyedrop instillation. Each patient shall repeat 5 times. It is recorded for the accuracy rate of instillation into the conjunctival sac within 5 times; It is recorded for the times needed to successfully instil into the conjunctival sac; It is recorded for the times needed to successfully instil into the conjunctival sac; it is recorded for the times without touching the skins around eye. Afterthat, our newly designed instillation process will be presented to patients, followed by a three-day-continuous recording for the patients' instillation process. Main Outcome Measures Counted times of instillation eyedrops into patients' conjunctival sac and eye skin areas touches by eyedrops bottle. Results Among 27 patients, the average year of using eyedrops was 1.70± 3.61. Within the 5 repeated tests, patients can successfully instil eyedrops into patients' conjunctival sac 3.00±1.82 times, with the cost of 7.15±1.97 drops on average. Within the 5 repeated tests, 0.37±1.33 tests had no eye skin areas touches by eyedrops bottles on average. After 3 days using our method, within the 5 repeated tests, patients can successfully instil eyedrops into patients' conjunctival sac 4.62±0.63 times, with the cost of 5.37±0.63 drops on average. Within the 5 repeated tests, none of eye skin areas touches caused by eyedrops bottles. The above mentioned indexes of comparison are statistically significant, with P indicator 0 for all. Conclusion It is observed that by using current instillation methodwould potentially cause several problems, including dropping the drug to the outer areas of conjunctival sac, so to cause a lot of pharmaceutical waste; potential infections caused by eye skin areas touches by eyedrops bottle, etc. By introducing the new instillation method, the above stated situation can be considerably improved, drug can be well treated to patients in higher efficiency, and the possibility of unnecessary infection by drug exposure to patients' eye skins can be avoided. (Ophthalmol CHN, 2013, 22: 357-360)

Key words: eyedrops, method of instillation, accuracy of instillation