Abstract: Objective To explore the 12-month efficacy of gonioscopy-assisted transluminal trabeculotomy (GATT) for juvenile open-angle glaucoma (JOAG)and primary open-angle glaucoma (POAG). Design Prospective study. Participants 37 patients (44 eyes) with JOAGand 25 patients (31 eyes) with POAG were enrolled from March 2018 to August 2019 in Beijing Tongren Hospital. Methods Prospective comparison of 12-month clinic outcome of GATT on JOAG and POAG. Main Outcome Measures Included intraocular pressure (IOP), the number of glaucoma medications, surgical success rate, and occurrence of complications. Success was defined as an IOP of ≤21 mmHg with (quantified success) or without (complete success) medication. Results At postoperative 12 months, both JOAG and POAG exhibited significant reduction IOP comparing with it preoperatively (JOAG group: t=6.564, P<0.001; POAG group: t=3.624, P=0.001). Additionally, there was a marked decrease in the number of anti-glaucoma medications in both groups (JOAG: t=16.386, P<0.001; POAG: t=7.977, P<0.001). The 3-month complete success rate of JOAG group (81.8%) was significantly higher than that in the POAG group (61.3%) (χ2=3.919, P=0.048). However, there was no significant difference of complete success rate at 1-, 6-, and 12-month between two groups. It was the same for 1-, 3-, 6-, and 12-month qualified success rate between two groups. In general,  early postoperative complications occurred in 72 (97.3%) eyes. Elevated IOP (63.64% in JOAG and 51.61% in POAG) and hyphema (79.55% in JOAG and 90.32% in POAG) happened most frequently, which were no significant differences between two groups. Conclusion The result of 12 months follow-up showed GATT is equally effective and safe for JOAG and POAG. (Ophthalmol CHN, 2024, 33: 275-279)

Key words: gonioscopy-assisted transluminal trabeculotomy, juvenile open-angle glaucoma, primary open-angle glaucoma