Abstract: Objective To systematically evaluate the effect of parental myopia on children's myopia. Design Meta analysis. Participants 46 Cohort studies, case-control studies and cross-sectional studies which were conducted for the effects of parental myopia on children's myopia. Methods The literatures in Pubmed, Web of science, Embase, CNKI and Wanfang database VIP and Chinese Biomedical literature Database from the January 2000 to September 2023 were searched. The included literature data were analyzed using the STATA (12.0) software package. Main Outcome Measures OR value. Results A total of 46 literatures (273 376 participants) were included, with 13 cohort studies, 5 case-control studies and 28 cross-sectional studies. The OR of giving birth to a child with myopia, according to the prospective cohort, cross-sectional and case-control studies was 1.73(95%CI, 0.96~3.13),2.05(95%CI, 1.74~2.42),2.51(95%CI,2.28~2.76). When one parent had myopia, the OR was 2.00(95%CI, 1.84~2.18), respectively, when two parents had myopia, the OR was 2.90(95%CI, 2.46-3.42). Conclusion There is a significant positive correlation between parental myopia and the risk of myopia in children. Myopia in one or both parents significantly increases the risk of myopia in their children. Children with myopia in both parents have a higher risk of myopia compared to those with myopia in one parent. (Ophthalmol CHN, 2024, 33: 368-376)

Key words: myopia, parental myopia, Meta-analysis