Abstract:  Objective To study the ophthalmic manifestation of patients with germinoma in sellar region. Design Retrospective case series. Participants 43 patients with germinoma in sellar region were collected from 2005 to 2010 in Beijing Tiantan Hospital. Method The visual acuity, fundus photographs and visual fields of patients were analyzed. The correlation analysis was performed between the vision, age  and course of disease. Main Outcome Measures Visual acuty, visual field and fundus manifestation. Result The average age of patients was 15.7±6.5(4~31) years-old. The median of corrected visual acuity was 0.15. There were 74.3% (52/70) eyes with decreased visual acuity, 74.2% (46/62) with the visual field defects, 39.7% (27/68) with fundus changes. A statistically significant correlation was found between the visual acuity and age(r=0.384, P=0.023). There was no statistically significant correlation between the visual acuity and the course of disease. Conclusion Germinoma in sellar region could cause severe eye dysfunction and the rate of blindness was very high. The younger the patient was, the heavier the impairment of vision was. （Ophthalmol CHN, 2012, 21: 313-315）

Key words: sellar germinoma/diagnosis, visual field, fundus