国际眼科纵览 ›› 2024, Vol. 48 ›› Issue (6): 411-415.doi: 10.3760/ cma.j.issn.1673-5803.2024.06.003

• 综述 • 上一篇    下一篇

人工晶状体表面改性防治眼内炎

郑鑫  万修华   

  1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室,北京 100730
  • 收稿日期:2022-10-19 出版日期:2024-12-22 发布日期:2024-12-06
  • 通讯作者: 万修华,Email:wanxh@ccmu.edu.cn
  • 基金资助:
    国家自然科学基金(82171037,82471055);北京市科技新星交叉联合课题(20240484565)

Surface modification of intraocular lenses for the prevention and treatment of endophthalmitis

Zheng Xin, Wan Xiuhua   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100730, China
  • Received:2022-10-19 Online:2024-12-22 Published:2024-12-06
  • Contact: Wan Xiuhua, Email: wanxh@ccmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(82171037, 82471055); Beijing New-Star Plan Science and Technology Cross Cooperation Project(20240484565)

摘要: 通过对人工晶状体(intraocular lens,IOL)表面进行改性可有效降低与白内障手术相关的眼内炎和术后感染的风险。根据IOL改性的效应材料,可以将IOL表面改性分为药物负载和非药物负载改性两大类。药物负载的IOL表面改性可通过“涂层”,如临界流体浸渍、聚合物/药物化学涂层技术及“浸泡”的方式来实现,将莫西沙星等抗生素负载于IOL表面,以预防眼内炎。对疏水性IOL进行表面亲水性修饰改性,抑制晶状体上皮细胞的黏附可预防后发障和眼内炎的发生。 (国际眼科纵览,2024, 48:411-415

关键词: 人工晶状体, 白内障, 眼内炎

Abstract: The surface modification of intraocular lens (IOL) can effectively reduce the risk of endophthalmitis and postoperative infection associated with cataract surgery. According to the effect materials modified by IOL, the surface modification of IOL can be divided into two categories, drug loading and non-drug loading modification. Drug-loaded IOL surface modification can be achieved by "coating", such as critical fluid impregnation, polymer/pharmaceutical chemical coating technology and "immersion". Antibiotics such as moxifloxacin are loaded on the surface of IOL to prevent endophthalmitis. Surface hydrophilic modification of hydrophobic IOL to inhibit the adhesion of lens epithelial cells can prevent the occurrence of after-cataract and endophthalmitis. (Int Rev Ophthalmol, 2024, 48:  411-415)

Key words: intraocular lens, cataract, endophthalmitis