关键词: IgG4相关性眼病, 纤维化, 黏膜相关淋巴组织淋巴瘤

Abstract: IgG4-related ophthalmic disease (IgG4-ROD) is an occult-progressive disease characterized by IgG4 and plasma cell infiltration, mattostriate fibrosis, and occlusive phlebitis in tumor-like tissues. At present, the pathogenesis and malignant mechanism of IgG4-ROD remain unclear. After pathogen infection, the pathogen recognition receptor encoded by the innate immune recognition germ line activates B cells, and promotes the activation and class switch to IgG4 of B cells with the assistance of Tfh cells, resulting in the infiltration of IgG4 in tissues. B cells activate cytotoxic T lymphocyte (CTL) cells, which together with CTL cells promote fibrosis. IgG4-ROD can malicious change into mucosa associated lymphoid tissue type (MALT),  immunity and inflammation may be involved in the pathogenesis.(Int Rev Ophthalmol, 2023, 47: 163-169)

Key words: IgG4-related ophthalmic disease, fibrous, mucosa associated lymphoid tissue type lymphoma