关键词: 帕金森病, 视网膜, 多巴胺

Abstract: Parkinson's disease (PD) is a neurodegenerative disease, which is pathologically characterized by progressive neurodegeneration of the nigrostriatal dopamine system. In addition to showing motor symptoms such as rest tremor, PD patients also have non-motor symptoms such as visual impairment. It has been shown that changes of retinal and visual dysfunction in PD patients are biological signals, which appear earlier than the motor symptoms. At present, several studies have found that the imbalance between dopamine and melatonin and the accumulation of α-synuclein are related to retinal changes of PD. At the same time, the thickness of the retinal nerve fiber layer (RNFL) and the macular area in PD patients will become thinner, and a certain degree of visual impairments will appear.(Int Rev Ophthalmol, 2020, 44: 438-442)

Key words: Parkinson's disease, retina, dopamine ,