Abstract: 【Abstract】With the development of tissue engineering and cell engineering, the studies of tissueengineered cornea have made great progress. Technique of corneal endothelial cells culturing in vitro lays a solid foundation for tissue engineering corneal endothelial transplantation. The maturity of the technique to replace decompensated corneal endothelial cells with the reconstructed, including to  plant the different sources of corneal endothelial seed cells in a suitable biomaterialscaffold, will bring new hope for patients with corneal endothelial related blindness. (Int Rev Ophthalmol, 2012, 36: 416-421）