Abstract: Coats disease is mostly unilateral and affects mainly males during childhood. It characterizes by retinal telangiectasis, intraretinal and subretinal exudation. The pathogenesis of Coats dieases is still unclear. The affected eye usually has poor prognosis, and enucleation may be considered in some of severe patients. In current, the pathogenesis is considered related to the vascular factors, genes, and cytokines. The treatments of Coats disease include laser, cryotherapy, and medications, and the combined therapy is the commom choice. The vitrectomy can be choose for the refractory cases, while the surgery should be carefully choosed.