国际眼科纵览

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眼前段药物缓释系统研究进展

刘晓岸  余敏斌   

  1. 510060 广州,中山大学附属眼科医院中山大学中山眼科中心眼科学国家重点实验室
  • 收稿日期:2014-11-13 出版日期:2015-10-22 发布日期:2015-10-27
  • 通讯作者: 余敏斌
  • 基金资助:

    教育部博士点专项基金(20120171130013);广东省科技计划项目(2012B0131800461)

Advance on anterior segment ocular drug sustained delivery systems

LIU Xiao-an,YU Min-bin.   

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
  • Received:2014-11-13 Online:2015-10-22 Published:2015-10-27
  • Contact: YU Min-bin

摘要:

目前眼前段药物缓释系统的研究主要有前体药物、佐剂、聚合物凝胶和胶体剂型等。前体药物和佐剂研究较早,应用较多;聚合物凝胶、胶体剂型等具有更好的药物缓释性、更高的生物利用度且患者舒适度较高,是现在眼部用药研究的热点。(国际眼科纵览,2015,  39: 297.302)

Abstract:

At present, researches in drug release system for ocular anterior segment including pro-drug, polymer gel, additives and colloid dosage forms. Pro-drug and additives have an earlier research and wider application. Polymer gel and colloid dosage forms become the focus of the research for its better advantage of drug sustained release, high bio\|availability as well as patient’s comfort and tolerance.   (Int Rev Ophthalmol, 2015, 39:  297.302)