Abstract:

Age-related macular degeneration (AMD) is one of the most common causes of blindness in 50 year-old or more patients in the developed country. While the pathogenesis is complicated, many cytokines are involved in wet AMD pathogenesis, such as vascular endothelial growth factor, basic fibroblast growth factor, tumor necrosis factor-α, transforming growth factor, matrix metalloproteinases, insulin-like growth factor 1, angiopoietin, platelet derived growth factor and hepatocyte growth factor, which play important roles in promoting angiogenesis, inflammation and fibrosis. Action mechanisms investigations on those associated cytokines may represent potential therapeutic targets for AMD.(Int Rev Ophthalmol,2015,39:327.332)