Abstract:

Pterygium is a common ocular surface disease in China, which is mainly related to UV light exposure. Peroxiredoxin 2 (Prx2), an antioxidant enzyme, can reduce reactive oxygen species caused by ultraviolet radiation, and its functional role in signal transduction also been confirmed. Early studies demonstrated that prx2 involved in the several cancers, and prx2 could be a potential target of cancer treatment. Initial studies also supported the proposal that Prx2 could be involved in the development of pterygium. However, the molecular mechanism of Prx2 in pterygium is poorly understood. Prx2 plays dual roles as both antioxidant enzyme and molecular chaperone, which acts a sensor for H2O2 and signaling pathways. The development of Prx2 inhibitors will facilitate the experimental and application research on Prx2 Further studies are required to test the hypothesis that Prx2 could be a potential target of pterygium treatment.