Abstract:

Tacrolimus (FK506), a novel immunosuppressant, has been used in liver transplantation and atopic dermatitis since it was discovered in 1984. In the field of eye diseases, eyedrops of tacrolimus has shown efficacy in immune-based inflammatory disorders (such as immune conjunctival and corneal diseases including vernal keratoconjunctivitis, refractory allergic conjunctivitis and autoimmune conjunctivitis). As research developed, eyedrops of tacrolimus has been widely applied in graft-versus-host disease, corneal graft rejection, and oral or intravitreal injection of tacrolimus applied in refractory uveitis. (Int Rev Ophthalmol, 2018, 42:  318-322)