Abstract: Immune mechanism plays an important role in pathology of AMD, including formation of drusen, geographic atrophy and choroidal neovascularization (CNV). Retina is an "immune privileged" site, which could maintain immune homeostasis in one's life. Disruption of this homeostatic mechanisms seems crucial in allowing excessive activation of immunologic response and the resultant chronic inflammation, which could lead to accumulation of resident immune cells, complement components and deposition of immune complex, all above may result in ocular tissue damage and degeneration. At present, deposition of immunoreactive products in ocular tissues is involved in chronic inflammation, parainflammation, dysfunction of autophagy and so on. This article  reviews recent studies on development of AMD relevant to retina aging, dysfunction of immunity and autophagy.