Abstract: Drug-induced dry eye is gradually recognized by ophthalmologists in recent years. It has been found that more than 10 categories and hundreds of drugs can induce dry eye, which include anticholinergic receptor drugs, antihistamines, antidepressant drugs, antipsychotic drugs, hormone drugs, antiglaucoma drugs, and so on. The main mechanisms include the influence of drugs on the parasympathetic/sympathetic system so that the secretion pathway of lacrimal gland blocked, or tear film instability and ocular surface abnormalities caused by eye drops or ointments. Preventions and treatments are mainly to stop or change the drugs, etiological treatment and symptomatic treatment.