Abstract: Meibomian gland dysfunction (MGD) is the general term that describes a chronic, diffuse abnormality of the meibomian glands, commonly characterized by terminal duct obstruction or/and qualitative and quantitative changes in the meibom secretion. It may result in instability of the tear film, inflammation in the lid margin, lipid tear deficiency(LTD) dry eye and other ocular surface diseases. Previously, MGD treatment includes the eyelids cleaning, warm massage, nutritional therapy, hormone and antibiotic applications. In recent years，physical therapy, immune regulation, and environmental regulation, as well as the study of the mechanism of antibiotic application, has a lot of new progresses.