Abstract: 【Abstract】The extracellular matrixassociated signaling protein CCN1, also named Cyr61, is the first cloned member of CCN family, which is identified as a secreted, cysterinerich, heparin binding protein induced by growth factors. As an important regulator in extracellular matrix (ECM), it has been shown to mediate functions as diverse as cell adhesion, proliferation, migration, adhesion and differentiation. It also plays vital roles in many complex processes, such as angiogenesis, wound repair, inflammation and tumorigenesis. Resent studies have found that CCN1/Cyr61 involved in the process of neovascularization, proliferation and fibration of the retina and is correlated with the occurrence and development of diabetic retinopathy. (Int Rev Ophthalmol, 2012, 36: 379-382)